Dr. Peter Farrell, ResMed Founder and Chairman , identifies key research findings that are shaping the field of sleep medicine today.
Dr. Peter C. Farrell PhD, DSc, AM is a graduate of the University of Sydney, the Massachusetts Institute of Technology, the University of Washington, Seattle, and the University of New South Wales. More about Peter
Unexpectedly high prevalence of sleep disordered breathing in a population
CPAP therapy can reverse systolic and diastolic abnormalities in OSA sufferers as early as 3 months into therapy
Colish J, Walker J, Elmayergi N, Almutairi S, Alharbi F, Lytwyn M, Francis A, Bohonis S, Zeglinski M, Kirkpatrick I, Sharma S, Jassal D. Obstructive sleep apnea: Effects of continuous positive airway pressure on cardiac remodeling as assessed by cardiac biomarkers, echocardiography, and cardiac MRI. Chest 2012 141(3):674–81
Comorbidity of OSA and cardiovascular disease suggest OSA as a novel target for risk reduction
CPAP withdrawal leads to rapid recurrence of OSA, subjective sleepiness, impaired endothelial function and cardiovascular impacts
Kohler M, Stoewhas A, Ayers L, Senn O, Bloch K, Russi E, Stradling J. The effects of CPAP therapy withdrawal in patients with obstructive sleep apnea: a randomised controlled trial. Am J Respir Crit Care Med 2011 doi:10.1164/rccm.201106-0964OC.
High prevalence of OSA in AAA patients suggest OSA may be a causal factor for faster AAA expansion
Concomitant endothelial dysfunction and impaired myocardial perfusion present in subjects with moderate-to-severe obstructive sleep apnea, and effective CPAP treatment reverses many of these macrovascular/microvascular abnormalities
Butt M, Khair O, Dwivedi G, Shantsila A, Shantsila E, Lip G. Myocardial perfusion by myocardial contrast echocardiography and endothelial dysfunction in obstructive sleep apnea. Hypertension 2011;doi:10.1161/HYPERTENSIONAHA.111.170910
CPAP improves endothelial function in OSA patients
Sleep Heart Health Study: Strong association between ischemic stroke and OAHI in community-dwelling men with mild to moderate sleep apnea suggests appropriate target for future stroke prevention trials
Handelsman Y, Mechanick J, Blonde L, Grunberger G, Bloomgarden Z, Bray G, Dagogo-Jack S, Davidson J, Einhorn D, Ganda O, Garber A, Hirsch I, Horton E, Ismail-Beigi F, Jellinger P, Jones K, Jovanovič L, Lebovitz H, Levy P, Moghissi E, Orzeck E, Vinik A, Wyne K. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for Developing a Diabetes Mellitus Comprehensive Care Plan. Endocr Pract 2011;17(2)1-53
Treatment of OSA may improve macrovascular outcomes in type 2 diabetes patients